TFT Set 13 Guide: 6 Bruiser Twitch Caitlyn

In TFT Set 13, combining the Bruiser, Experiment, Enforce, and Sniper traits creates a powerful composition that leverages both high health and long-range damage. This guide covers a 6-Bruiser setup with Caitlyn as the main carry and Twitch as the secondary, supported by Nunu and Elise as tanky Bruisers. With a mix of strong frontline durability and high-impact ranged attacks, this build excels at controlling battles by picking off priority targets from afar.

See more: How to Play Bruiser

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1. Main Carry: Caitlyn (5g)

As the primary carry, Caitlyn benefits from both the Sniper and Enforcer traits. Sniper grants her bonus damage based on distance, allowing her to hit harder from the backline. Meanwhile, her Enforcer trait provides shields, damage amplification, and the unique “Wanted” mechanic, which marks high-health enemies for bonus damage. With these bonuses, Caitlyn can quickly shred key targets, especially when paired with the right items.

2. Secondary Carry: Twitch (4g)

Twitch is the secondary damage dealer and pairs well with Caitlyn, benefiting from the Sniper trait for increased range damage. His Experiment trait enables him to stand on Laboratory hexes, gaining additional health and the combined bonuses of other Experiment units in these hexes. Position him to optimize his long-range attacks and amplify the team’s backline damage.

3. Frontline Tanks: Nunu & Willump (3g) and Elise (4g)

Nunu and Elise act as the primary tanks, benefiting from the Bruiser trait’s health bonus to withstand prolonged battles. Their combination of high durability and Experiment bonuses makes them extremely tough, helping protect Caitlyn and Twitch while they unleash damage from a safe distance.

4. Additional Bruisers: Steb (1g), Trundle (1g), Sett (2g), and Renni (3g)

These units complete the Bruiser synergy, providing a total of 6 Bruisers, which grants all Bruisers an impressive health boost. The extra health keeps the frontline resilient, maintaining a solid defense that buys time for the carries to maximize their damage output.

• Bruiser (6): Grants all units bonus health, with Bruisers gaining even more. This makes your frontline incredibly tanky and gives your backline the space they need to dish out high DPS.

• Enforce (2): With Steb and Caitlyn as Enforcers, you gain shield and damage amplification, and the highest-health enemy is marked as "Wanted." This trait allows your team to focus down priority targets with boosted damage and adds attack speed to Enforcers when a “Wanted” enemy is killed.

• Experiment (3): Adds two Laboratory hexes on the board. Units standing in these hexes gain the combined Experiment bonuses of all other Experiments in the hexes and extra health. Placing Twitch, Nunu, and Dr. Mundo in these hexes ensures they receive maximum health and additional Experiment effects.

• Sniper (2): Snipers, including Caitlyn and Twitch, deal more damage based on distance, allowing them to deliver powerful strikes from the backline. This bonus turns Caitlyn and Twitch into formidable long-range threats, especially when properly positioned.

1. Early Game Strategy

In the early game, prioritize acquiring Steb, Trundle, and Sett to start building your Bruiser frontline. These units are cost-effective and durable, giving you an early advantage by keeping your team alive and absorbing damage. Look to acquire Caitlyn and Twitch as soon as possible to begin building up your carry potential, though you can focus on itemizing Caitlyn first as she will serve as the primary carry.

2. Mid to Late Game Transitions

By mid-game, aim to reach 6 Bruisers by adding Nunu, Renni, and Elise, creating a solid frontline. Look for Dr. Mundo and the final core units to complete your Experiment trait, providing powerful bonuses for units on Laboratory hexes. Position Twitch and Caitlyn in the backline to optimize their Sniper damage, making the most of the distance-based damage scaling.

• Caitlyn: Infinity Edge, Last Whisper, Jeweled Gauntlet

Infinity Edge and Jeweled Gauntlet allow Caitlyn’s abilities to crit for high damage, while Last Whisper reduces the armor of high-health enemies, helping her tear through tanks and squishy targets alike.

• Twitch: Guinsoo's Rageblade, Rapid Firecannon, Runaan’s Hurricane

Guinsoo’s Rageblade helps Twitch scale attack speed over time, and Rapid Firecannon increases his range, keeping him at a safe distance. Runaan’s Hurricane allows him to hit additional targets, maximizing his DPS output.

• Nunu: Warmog’s Armor, Sunfire Cape

These items provide Nunu with a massive health pool and consistent burn damage with Sunfire Cape, making him an even more formidable tank in the frontline.

• Elise: Gargoyle Stoneplate, Redemption

Gargoyle Stoneplate grants Elise additional armor and magic resistance when surrounded, while Redemption offers healing, helping sustain your team during prolonged fights.

• Place Bruisers in the front to absorb damage, with Nunu and Elise positioned at the center to maximize their tanking potential.
• Position Caitlyn and Twitch in the back corners, separated from each other to minimize the risk of AOE damage, allowing them to benefit from Sniper’s bonus distance-based damage.
• Position Dr. Mundo and other Experiment units on Laboratory hexes to maximize their health and share Experiment bonuses.

This 6-Bruiser Twitch Caitlyn composition in TFT Set 13 is a well-rounded setup that combines the durability of Bruisers with the high-damage potential of Sniper carries. Caitlyn and Twitch can consistently deal critical damage from a distance while supported by a resilient frontline. With strategic positioning and optimized itemization, this build is a flexible and powerful option for those looking to climb the ranks in TFT Set 13. Experiment with positioning, itemization, and carry prioritization to get the most out of this comp and secure victories in the late game!

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Good luck to you! – Cheng